Detailed view for TVAG_143480

Basic information

TDR Targets ID: 927365
Trichomonas vaginalis, Rab6, putative
Source Database / ID: 

pI: 7.2658 | Length (AA): 220 | MW (Da): 24758 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00071   Ras family

Gene Ontology

Mouse over links to read term descriptions.
GO:0005525   GTP binding  
GO:0003924   GTPase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128084)

Species Accession Gene Product
Arabidopsis thaliana AT5G57960   GTP-binding protein, HflX
Arabidopsis thaliana AT3G49725   GTP-binding protein, HflX
Brugia malayi Bm1_12380   MGC83645 protein
Caenorhabditis elegans CELE_F46B6.4   Protein F46B6.4
Chlamydia trachomatis CT_379   GTPase HflX
Drosophila melanogaster Dmel_CG5116   CG5116 gene product from transcript CG5116-RB
Escherichia coli b4173   GTPase, stimulated by 50S subunit binding
Echinococcus granulosus EgrG_000853800   GTP binding protein hflx
Echinococcus multilocularis EmuJ_000853800   GTP binding protein hflx
Homo sapiens ENSG00000178605   GTP binding protein 6 (putative)
Loa Loa (eye worm) LOAG_03897   hypothetical protein
Mycobacterium leprae ML0997   PROBABLE GTP-BINDING PROTEIN HFLX
Mus musculus ENSMUSG00000033434   GTP binding protein 6 (putative)
Mycobacterium tuberculosis Rv2725c   Probable GTP-binding protein HflX
Mycobacterium ulcerans MUL_3368   GTP-binding protein HflX
Neospora caninum NCLIV_029330   hypothetical protein
Oryza sativa 4350828   Os11g0592700
Oryza sativa 4333978   Os03g0727900
Onchocerca volvulus OVOC13458  
Plasmodium berghei PBANKA_0934100   GTP-binding protein, putative
Plasmodium falciparum PF3D7_1113500   GTP-binding protein, putative
Plasmodium knowlesi PKNH_0911100   GTP-binding protein, putative
Plasmodium vivax PVX_091320   hypothetical protein, conserved
Plasmodium yoelii PY00735   Y14391 GTP-binding protein
Schistosoma japonicum Sjp_0038540   ko:K03665 GTP-binding protein HflX, putative
Schistosoma mansoni Smp_016550.1   GTP-binding protein hflx
Schistosoma mansoni Smp_016550.2   GTP-binding protein hflx
Schmidtea mediterranea mk4.047236.00  
Schmidtea mediterranea mk4.000948.03   Putative gtp-binding protein hflx
Toxoplasma gondii TGME49_255470   hypothetical protein
Trichomonas vaginalis TVAG_143480   Rab6, putative

Essentiality

TVAG_143480 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2771 Mycobacterium tuberculosis non-essential nmpdr
b4173 Escherichia coli non-essential goodall
PBANKA_0934100 Plasmodium berghei Essential plasmo
TGME49_255470 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_143480 (Trichomonas vaginalis), Rab6, putative
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